The relationship between serum copper, zinc, and glutathione peroxidase with malondialdehyde in women with unexplained recurrent miscarriage

Abstract EN

The study was designed to evaluate the relationship between serum copper, serum zinc, also with malondialdehyde (MDA) in women with unexplained recurrent miscarriage. Also, the study evaluated the relationship between glutathione peroxidase with malondialdehyde (MDA) in women with unexplained recurrent miscarriage.

Blood samples were take from obstetric and gynecology outpatient departments of a ministry of healthy hospitals.

Patient women with, at least, three consecutive fetal losses. Seventy five women with unexplained recurrent miscarriages (study group) and eighty healthy controls (group control) with no antecedent fetal loss.

We found that significantly increased lipid peroxidation, measured as MDA, was demonstrated in women with unexplained recurrent (p < 0.02).

The mean serum copper level in in women with unexplained recurrent was significantly lower than the control group (p < 0.01).

In addition, the mean serum zinc level in women with unexplained recurrent was significantly lower than the control group (p < 0.04), and the mean serum glutathione peroxidase level in patients with miscarriage was significantly lower than the control group (p < 0.024).

Moreover, a negative correlation was also observed between glutathione peroxidase, copper, zinc with MDA levels in the patient group but not in the control group.