The ability of albumin and cysteine to mitigate toxic effect of acrylamide in rats

Abstract EN

The toxic effects of acrylamide (ACR) on adult male albino rats and the effect of albumin and cysteine administration to mitigate such toxicity were studied.

Fifty six adult male Sprague- Dawley rats were divided into seven groups.

The first group served as normal control fed on basal diets, the second and third groups fed on basal diets and received low dose (15 mg/kg body weight) or high dose of ACR (30 mg/kg body weight) respectively.

The fourth and fifth groups fed on basal diets and received low dose or high dose of ACR mixed with 10mg albumin/1mg ACR respectively.

The sixth and seventh groups fed on basal diet and received low dose or high dose of ACR mixed with10mg cysteine/1mg ACR respectively.

ACR, albumin and cysteine were given by oral gavage administrations 5 times weekly for 6 weeks.

The results showed that ACR administration induced significant elevation of hepatic malondialdehyde level (MDA), serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, blood urea and serum creatinine levels.

The treatment with albumin or cysteine significantly decreased the elevated levels.

On the other hand, ACR induced a significant reduction of the hepatic glutathione content (GSH), brain deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) contents as well as marked decrease of testosterone level.

The treatment with albumin or cysteine induced a significant increase of the previous parameters.

It can be concluded that both albumin and cysteine may play a role in reducing the toxic effects of acrylamide.