Effect of banana on the metabolism of vitamin b6 in the male rats

Abstract EN

For years it has been known that certain fruits interact with certain drugs.

The coadministration of the drugs with those fruits can elevate drug bioavailability and can change pharmakintic and pharmacodinamic parameters of the drugs.

(1) This phenomenon depends mainly on the inhibition of cytochrome 450 3A4 in the cells of small intestine leading to reduction of drug pre-systemic metabolism.

(2) In addition to that it has been presumed that fruit in turn inhibits P-glycoprotein which is a carrier that transport drug from the cells of the intestine back to the intestinal lumen, a process that increases the amount of drug absorbed.(3) In this experiment we aim to know effect of banana juice on the metabolism of vitamin B6 in the rats male.

Thirty male rats were divided into three groups.

Two groups were administered vit.

B6 dissolved in water for one of them, and in banana juice for the other group, while the third group received banana juice without vit.

B6, after three hours of administration there were significant differences in the concentration of plasma vit.

B6 among the groups (P < 0.01).