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Chromosome abnormalities of oral squamous cell carcinoma and correlation to the tumor size and TNM staging
Joint Authors
al-Mualla, Haydar Dakhil
Sami, Suha Muhammad
Kammunah, Raja K.
al-Taha, Salma A. H.
Source
Issue
Vol. 12, Issue 1 (30 Jun. 2009), pp.355-366, 12 p.
Publisher
University of Kufa Faculty of Medicine
Publication Date
2009-06-30
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Abstract EN
It is well established that cancer is a multistage process involving a number of aberrant molecular events culminating in malignant transformation.
Indeed the great majority of human cancers exhibit quite visible chromosome changes and the consistent chromosome abnormalities are essential for the malignant phenotype, the aim of the preset study designed to asses the chromosomal aberration and the possible correlation with tumor size and TNM staging (T tumor size, N lymph node involvement, M tumor metastasis) of oral squamous cell carcinoma .
We assessed the chromosomal aberration of sixteen patients with oral squamous cell carcinoma were studied, fresh and solid tumor was taken for mincing and transferred to a new tissue culture media, chromosomes staining was carried out with trypsin-Geimsa banding. The results of the present studies showed Aneuploidy,loss of chromosomes, deletion of chromosomal 7 Ch7q (22→ 36), translocation t (7 : 4q) (22 →36 : : 35 ) and dicentric chromosome and double minutes.
Tumor size (T3 +T4 +TX ) only represented a positive findings.
TNM staging only stage (III+IV) represented a positive chromosomal aberration. In conclusion there was no specific chromosome or chromosomal aberration associated with oral squamous cell carcinoma.The tumor size and TNM staging system can be consider as a good clinical predictors for treatment plane and prognosis .
American Psychological Association (APA)
al-Mualla, Haydar Dakhil& Sami, Suha Muhammad& Kammunah, Raja K.& al-Taha, Salma A. H.. 2009. Chromosome abnormalities of oral squamous cell carcinoma and correlation to the tumor size and TNM staging. Kufa Medical Journal،Vol. 12, no. 1, pp.355-366.
https://search.emarefa.net/detail/BIM-326820
Modern Language Association (MLA)
al-Mualla, Haydar Dakhil…[et al.]. Chromosome abnormalities of oral squamous cell carcinoma and correlation to the tumor size and TNM staging. Kufa Medical Journal Vol. 12, no. 1 (2009), pp.355-366.
https://search.emarefa.net/detail/BIM-326820
American Medical Association (AMA)
al-Mualla, Haydar Dakhil& Sami, Suha Muhammad& Kammunah, Raja K.& al-Taha, Salma A. H.. Chromosome abnormalities of oral squamous cell carcinoma and correlation to the tumor size and TNM staging. Kufa Medical Journal. 2009. Vol. 12, no. 1, pp.355-366.
https://search.emarefa.net/detail/BIM-326820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 364-366
Record ID
BIM-326820