Possible association of HLA class-I molecules with autoimmune hepatitis in Iraqi patients

Abstract EN

Background : genetic factors were considered to play a possible role the development of autoimmune hepatitis. Patients and methods : polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls. Results : comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies.

HLA-A * 113 (A1 / - / Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B * 8 and B * 14 were statistically significant in AIH which is most likely to be considered as a rather risk factor, while most HLA-B * 16 were lost which led us to think of being acting as a rather protective factor. Conclusions : this finding reflects a preliminary picture that HLA antigens might play a role in AIHsusceptibility and further studies are worth being carried out.