The effect of subacute exposure of prednisolone in liver and kidney functions in males albino rats
Joint Authors
al-Rikabi, Falah Musa Kazim
al-Bakka, Husayn Abd Allah Abd al-Rida
al-Jabburi, Zaynab Tawfiq Shanawa
Source
Issue
Vol. 12, Issue 1 (30 Jun. 2009), pp.394-400, 7 p.
Publisher
University of Kufa Faculty of Medicine
Publication Date
2009-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
This study is dealing in animal house in college of Medicine / Kufa University.
Which is conducted to study the effect of subacute exposure of prednisolone drug on some liver enzymes (ALT,AST and AP), and Blood Urea (BU) by administration of different doses of prednisolone in (18) of Albino Swiss males rats by stomach tube for duration (21) days. The results showed significantly increase in serum level of (ALT) for (T2) group of animals at level (p50.01) in comparison to (T1) and (C) groups of animals, while the serum level of (AST) revealed significantly increase in both (T1 and T2) group of animals at level (p50.01) in comparison with (C), furthermore, the levels of (BU) showed significantly increase at level (p50.01) in (T2) group of animals in comparison with (T1) and (C), but there is no significantly changes in serum levels of (AP) at level (p50.05) between all groups of treatment and control. The histopathological examination for livers and kidneys revealed mild degeneration with cytoplasmic vacuolation in livers of (T1) group animals, while there are multinecrosis areas in livers of (T2) group animals.
In contrast with control group which had no histopathological changes , while the biopsy or (histopathological) changes in kidneys of (T2) group animals appeared extensive tubular necrosis with areas of hemorrhage.
American Psychological Association (APA)
al-Rikabi, Falah Musa Kazim& al-Bakka, Husayn Abd Allah Abd al-Rida& al-Jabburi, Zaynab Tawfiq Shanawa. 2009. The effect of subacute exposure of prednisolone in liver and kidney functions in males albino rats. Kufa Medical Journal،Vol. 12, no. 1, pp.394-400.
https://search.emarefa.net/detail/BIM-326874
Modern Language Association (MLA)
al-Rikabi, Falah Musa Kazim…[et al.]. The effect of subacute exposure of prednisolone in liver and kidney functions in males albino rats. Kufa Medical Journal Vol. 12, no. 1 (2009), pp.394-400.
https://search.emarefa.net/detail/BIM-326874
American Medical Association (AMA)
al-Rikabi, Falah Musa Kazim& al-Bakka, Husayn Abd Allah Abd al-Rida& al-Jabburi, Zaynab Tawfiq Shanawa. The effect of subacute exposure of prednisolone in liver and kidney functions in males albino rats. Kufa Medical Journal. 2009. Vol. 12, no. 1, pp.394-400.
https://search.emarefa.net/detail/BIM-326874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 399-400
Record ID
BIM-326874