The effect of subacute exposure of prednisolone in liver and kidney functions in males albino rats

Abstract EN

This study is dealing in animal house in college of Medicine / Kufa University.

Which is conducted to study the effect of subacute exposure of prednisolone drug on some liver enzymes (ALT,AST and AP), and Blood Urea (BU) by administration of different doses of prednisolone in (18) of Albino Swiss males rats by stomach tube for duration (21) days. The results showed significantly increase in serum level of (ALT) for (T2) group of animals at level (p50.01) in comparison to (T1) and (C) groups of animals, while the serum level of (AST) revealed significantly increase in both (T1 and T2) group of animals at level (p50.01) in comparison with (C), furthermore, the levels of (BU) showed significantly increase at level (p50.01) in (T2) group of animals in comparison with (T1) and (C), but there is no significantly changes in serum levels of (AP) at level (p50.05) between all groups of treatment and control. The histopathological examination for livers and kidneys revealed mild degeneration with cytoplasmic vacuolation in livers of (T1) group animals, while there are multinecrosis areas in livers of (T2) group animals.

In contrast with control group which had no histopathological changes , while the biopsy or (histopathological) changes in kidneys of (T2) group animals appeared extensive tubular necrosis with areas of hemorrhage.