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Lymphocyte subsets phenotype in patients with infectious mononucleosis
Author
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 51, Issue 2 (31 Dec. 2009), pp.227-231, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2009-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Infectious mononucleosis (IM) is a lymphoproliferative disease caused primarily by the Epstein-Barr virus (EBV) infection.
The initial viral infection by EBV occurs in B lymphocytes and is followed by an extensive proliferation of T lymphocytes.
Previous studies on immunity to EBV (including IM) have mainly focused on activation of peripheral blood T cells, which are responsible for the lymphocytosis in blood during acute IM. Patients and Methods : Indirect immunofluorescence technique analysis was performed to detect the percentage of CD3, CD4, CD8, CD19, and CD56 positive lymphocytes. Results : Our results on the phenotype of T cells in samples from patients with infectious mononucleosis showed that there is a significant increase in percentage of CD8+ T-cells when compared with healthy group.
In addition, increased in percentage of CD3 T-cells and moderately increase in CD56 (NK) cells.
CD4 and CD19 percentage were significantly decrease in comparison with healthy control. Conclusion : Acute infectious mononucleosis is characterized by a marked increase in the percentage of CD3 and CD8 T- cells with a slight increase in CD56 percentage.
A marked decrease in CD19 percentage and CD4 / CD8 ratio was noticed.
American Psychological Association (APA)
Salih, Shahla Mahdi. 2009. Lymphocyte subsets phenotype in patients with infectious mononucleosis. Journal of the Faculty of Medicine Baghdad،Vol. 51, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-326882
Modern Language Association (MLA)
Salih, Shahla Mahdi. Lymphocyte subsets phenotype in patients with infectious mononucleosis. Journal of the Faculty of Medicine Baghdad Vol. 51, no. 2 (2009), pp.227-231.
https://search.emarefa.net/detail/BIM-326882
American Medical Association (AMA)
Salih, Shahla Mahdi. Lymphocyte subsets phenotype in patients with infectious mononucleosis. Journal of the Faculty of Medicine Baghdad. 2009. Vol. 51, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-326882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 230-231
Record ID
BIM-326882