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Molecular detection and genotyping of human papilloma virus infections in Iraqi patients with esophageal carcinoma
Joint Authors
Jumah, Intisar M.
Bakr, Tural Y.
Ali, Sad H. Muhammad
Ardalan, Dilaram M. M.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 51, Issue 2 (31 Dec. 2009), pp.204-210, 7 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2009-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Molecular DNA hybridization has confirmed more than 120 different human papilloma virus (HPV) genotypes.
A small group of them have high- risk oncogenic potential.
Many studies have described an association of such high risk-HPV genotypes with a variety of esophageal benign tumors as well as malignant squamous cell carcinomas. Patients and Methods : A total number of 90 tissue specimens were collected from 50 patients with esophageal squamous cell (SCC), adenocarcinoma (AC) and carcinoma in situ (CIS); 20 patients with squamous acanthosis (SA); and 20 individuals with apparently-healthy esophageal tissues (AHET).
The molecular detection methods for HPV detection and genotyping were performed by in situ hybridization using cocktailed- and specific high- risk HPV DNA probes, respectively. Results : The overall percentage of HPV in the total group of esophageal carcinoma was 20 %.The percentage of HPV DNA in the subgroup of SCC and AC was 26.7 % and 13.3 %, respectively,.
However, neither HPV DNA was detected in CIS subgroup nor in both control groups (SA and AHET).The overall genotyping results showed that HPV 18 constituted the majority of the detected high-risk oncogenic HPV genotypes, followed by HPV 16 then HPV 31 / 33. Conclusions : Despite the low prevalence of HPV infection and rarity of invasive esophageal carcinoma in the general Iraqi population, the detection of high percentage of such high oncogenic risk- HPV genotypes in these carcinomas indicating for a relevant importance in esophageal carcinogenesis.
American Psychological Association (APA)
Jumah, Intisar M.& Ali, Sad H. Muhammad& Bakr, Tural Y.& Ardalan, Dilaram M. M.. 2009. Molecular detection and genotyping of human papilloma virus infections in Iraqi patients with esophageal carcinoma. Journal of the Faculty of Medicine Baghdad،Vol. 51, no. 2, pp.204-210.
https://search.emarefa.net/detail/BIM-326894
Modern Language Association (MLA)
Jumah, Intisar M.…[et al.]. Molecular detection and genotyping of human papilloma virus infections in Iraqi patients with esophageal carcinoma. Journal of the Faculty of Medicine Baghdad Vol. 51, no. 2 (2009), pp.204-210.
https://search.emarefa.net/detail/BIM-326894
American Medical Association (AMA)
Jumah, Intisar M.& Ali, Sad H. Muhammad& Bakr, Tural Y.& Ardalan, Dilaram M. M.. Molecular detection and genotyping of human papilloma virus infections in Iraqi patients with esophageal carcinoma. Journal of the Faculty of Medicine Baghdad. 2009. Vol. 51, no. 2, pp.204-210.
https://search.emarefa.net/detail/BIM-326894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 209-210
Record ID
BIM-326894