Relationship between postprandial hyperglycemia and macroalbuminuria in type 2 diabetics

Abstract EN

Background With the recent development of new methods to measure postprandial hyperglycemia and new treatment to modulate it ,investigations have questioned whether postprandial hyperglycemia causes diabetic complications such as nephropathy. Objectives The aim of our study was to assess the influence of postprandial hyperglycemia on the incidence of nephropathy in patients with type 2 diabetics) Patients and methods the study was between 9 / 1 / 2008 to 14 / 11 / 2008.

100 patients attending diabetic clinic in Al-Dewania teaching hospital fulfilled in the criteria of the study .The patients investigated for macroalbuminuria .the Patients divided into two groups according to the results of 2 successive measurements of post –challenge plasma glucose level (following 75 gm glucose solution ) 2 weeks apart. Results Of total 100 patients with mild –moderate type 2 diabetes for last 5-7 years ,about 68 patients (68 %) had post prandial plasma glucose values > 200 mg / dl, 32 (32 %) patients of them had macroalbuminuria, whereas macroalbuminuria observed in 6 patients only (6 % of total) in those with post prandial plasma glucose < 200 (mg / dl total ).

Macroalbuminuria reported in 7 patients (of the total 100 had normal F P G. These finding suggest that patient with postprandial plasma glucose level > 200 mg / dl had more albumin excretion rate which is the predicator of nephrology.