Lipid peroxidation and caeruloplasmin levels in serum and saliva of acute myocardial infarction patients

Abstract EN

Background :- coronary artery disease is the major cause of mortality and morbidity.

There is substantial evidence that oxidative stress plays the major role in the atherosclerotic process.

Objectives :- this study was aimed to evaluate the levels of serum and saliva lipid peroxidation product malondialdyhyde (MDA) and caeruloplasmin in acute myocardial infarction (AMI) patients.

Materials and methods :- Fifty AMI patients with mean age of 54 ± 6.7 years and fifty control subjects with mean age 55 ± 6.2 years were incorporated in this study.

Blood and unstimulated saliva were collected from each subject.

Serum lipid profile was analyzed enzymatically.

Malondialdehyde (MDA) and caeruloplasmin levels in serum and saliva were estimated spectrophotometrically.

Results :- serum total cholesterol, triglycerides and LDL-cholesterol were significantly elevated in AMI patients compared with controls, while HDL-cholesterol was significantly decreased.

The levels of MDA and caeruloplasmin in serum and saliva were significantly raised (p < 0.001) in those patients.

Serum MDA and caeruloplasmin were significantly correlated with saliva MDA and caeruloplasmin (p < 0.001).

Conclusions :- oxidative stress was increased in AMI patient, in both serum and saliva, raised serum and saliva caeruloplasmin serve as a marker of chronic inflammation or it might be elevated as a consequence of oxidative stress in AMI patients.

Saliva is important for the evaluation of lipid peroxidation and antioxidants.