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The diagnostic value of immunohistochemistry in the diagnosis of primary and secondary hepatic carcinomas
Other Title(s)
الفائدة التشخيصية للصبغات المناعية في التفريق بين الأورام الأولية و الثانوية في الكبد
Author
Source
Journal of King Abdulaziz University : Medical Sciences
Issue
Vol. 16, Issue 4 (31 Dec. 2009), pp.37-48, 12 p.
Publisher
King Abdulaziz University Scientific Publishing Center
Publication Date
2009-12-31
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Topics
Abstract AR
أورام الكبد السرطانية الثانوية و الغير معروف مصدرها الأولي تعتبر مشكلة إكلينيكية.
و يطلب من أطباء علم الأمراض عادة الفريق بين الأورام السرطانية الأولية في الكبد و الأورام السرطانية الثانوية.
و لأن مكونات تلك السرطانات تتشابه لحد كبير في الاختبار النسيجي المجهري فإن استخدام الصبغات المناعية قد يكون له فائدة كبيرة في التفريق بين تلك الأورام.
و لكون بعض الصبغات المناعية التي استخدمت سابقا في ذلك الغرض لم تعد بفائدة كبيرة فقد تم اختبار مجموعة أخرى من تلك الصبغات المناعية لإجراء الدراسة عليها.
Abstract EN
Metastatic adenocarcinoma to the liver from an unidentified primary tumor site is a common diagnostic problem.
The present study included 41 cases of histologically diagnosed liver biopsies including hepatocellular carcinoma, cholangiocarcinoma and metastatic carcinoma in the liver.
All cases were stained immunohistochemically with Cytokeratin 7, 18 and 20, Carbohydrate Antigen 19-9 and Alpha-fetoprotein to evaluate their usefulness in differentiating these tumor entities.
Cytokeratin 18 was positive in 87.5 % of hepatocellular carcinoma; all cases of cholangiocarcinoma, and metastatic carcinoma.
Cytokeratin +7 ve / Cytokeratin 20-ve pattern was identified in 12.5 % of hepatocellular carcinoma, 100 % of cholangiocarcinoma, one metastatic pancreatic carcinoma, and all metastatic gastric carcinomas (100 %).
On the other hand, Cytokeratin 7-ve / Cytokeratin 20+ve were identified in colorectal carcinoma metastatic to the liver.
CA19-9 showed positive immunoreactivity in all studied cases.
AFP positive immunostaining was identified in 43.7 % of hepatocellular carcinoma while it was negative in all other tumors.
It was concluded that Cytokeratin 18 was of no benefit in the differential diagnosis of primary hepatic carcinoma and metastatic cases from any site.
Cytokeratin 7 and CA19-9 positive staining can exclude a diagnosis of hepatocellular carcinoma, but cannot discriminate between metastatic carcinoma (from stomach, pancreaticobiliary origin) and cholangiocarcinoma.
The Cytokeratin 20+ / Cytokeratin 7–ve phenotype indicates metastatic intestinal adenocarcinoma, most often from the colon or rectum.
American Psychological Association (APA)
Suwwan, Ali Sadiq. 2009. The diagnostic value of immunohistochemistry in the diagnosis of primary and secondary hepatic carcinomas. Journal of King Abdulaziz University : Medical Sciences،Vol. 16, no. 4, pp.37-48.
https://search.emarefa.net/detail/BIM-327500
Modern Language Association (MLA)
Suwwan, Ali Sadiq. The diagnostic value of immunohistochemistry in the diagnosis of primary and secondary hepatic carcinomas. Journal of King Abdulaziz University : Medical Sciences Vol. 16, no. 4 (2009), pp.37-48.
https://search.emarefa.net/detail/BIM-327500
American Medical Association (AMA)
Suwwan, Ali Sadiq. The diagnostic value of immunohistochemistry in the diagnosis of primary and secondary hepatic carcinomas. Journal of King Abdulaziz University : Medical Sciences. 2009. Vol. 16, no. 4, pp.37-48.
https://search.emarefa.net/detail/BIM-327500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 45-47
Record ID
BIM-327500