Intraoperative esmolol or lidocaine infusion spare postoperative opioid requirement in patients undergoing laparoscopic cholecystectomy

Abstract EN

Background / aim : This randomized, double blind, prospective study was undertaken to evaluate the effect of intraoperative infusion of esmolol or lidocaine on sparing postoperative opioid requirement and the incidence of postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy. Patients and methods : 75 patients (ASA physical status I) who underwent elective laparoscopic cholecystectomy were enrolled in this study ; they were randomly divided into 3 double blind group, 25 patients each.

Group I (esmolol group) : received esmolol continuous 10ug.

kg-1.

min-1 until the end of surgery.

Group II (lidocaine group) : received lidocaine continuous infusion 2 mg.

kg-1.

h-1 until the end of surgery.

Group III (control group): received normal saline 0.9 % infusion until the end of surgery.

General anesthesia was standardized in all three groups.

Patients were evaluated for postoperative pain, postoperative opioid enquiry, PONV, ondansetron enquiry and time till eligibility for discharge from post anesthesia care unit (PACU). Results : The number of patients experienced pain and required postoperative opioid were less in group I and II patients than group III.

The number of patients experienced PONV and required ondansetron were less in group I and II than group III.

The group I and II patients were faster discharged from post anesthesia care unit( PACU ) than group III patients but there was no difference between group I and II as regard pain or opioid enquiry, PONV, or stay in (PACU). Conclusion : intraoperative esmolol or lidocaine infusion spare postoperative opioid requirement with fewer incidences of postoperative nausea and vomiting (PONV) and rapid readiness for discharge from PACU in patients scheduled for laparoscopic cholecystectomy.