![](/images/graphics-bg.png)
Transcription factor activity profile of acute rejection after kidney transplantation
Joint Authors
Sui, Weiguo
Lin, Hua
Chen, Jiejing
Huang, He
Dai, Yong
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 3 (30 Jun. 2013), pp.480-486, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-06-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Transcription factors (TFs) play a central role in regulating gene expression and in providing an interconnecting regulatory between related pathway elements.
Currently, the widespread use of kidney transplantation to treat end-stage renal disease has evolved rapidly since the initial successful transplantations from both cadaveric and living donors.
However, acute rejection is still a strong risk factor for chronic rejection in recipients of renal grafts.
To investigate the possible mechanisms, we describe a comparison between TF' activity profile of acute rejection and controls.
Through TF assay analysis and electrophoretic mobility shaft assay confirmation, we identified the activities of TFs in acute rejection after kidney transplantation.
From a total of 345 screened TFs, 99 activity-differential TFs were found, of which 95 showed increased activity and four showed decreased activity.
Our data indicate that TFs may be potentially involved in the pathogenesis of acute rejection, and can help to prevent, diagnose and treat acute rejection after kidney transplantation.
The TF array methods could simplify the assay of multiple TFs and may facilitate high-throughput profiling of large numbers of TFs.
American Psychological Association (APA)
Sui, Weiguo& Lin, Hua& Dai, Yong& Chen, Jiejing& Huang, He. 2013. Transcription factor activity profile of acute rejection after kidney transplantation. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 3, pp.480-486.
https://search.emarefa.net/detail/BIM-328441
Modern Language Association (MLA)
Lin, Hua…[et al.]. Transcription factor activity profile of acute rejection after kidney transplantation. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 3 (Jun. 2013), pp.480-486.
https://search.emarefa.net/detail/BIM-328441
American Medical Association (AMA)
Sui, Weiguo& Lin, Hua& Dai, Yong& Chen, Jiejing& Huang, He. Transcription factor activity profile of acute rejection after kidney transplantation. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 3, pp.480-486.
https://search.emarefa.net/detail/BIM-328441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 485-486
Record ID
BIM-328441