Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis
Joint Authors
Sharifin, Mustafa
Ahmadi, Mitra
Karimi, Abd Allah
Zand, Rana Ismaili
Mughadar, Ruzbah
Ahmadi, Ruya
Chimeh, Masud Dadkhah
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 4 (31 Dec. 2013), pp.731-736, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-12-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Hydronephrosis is a common finding in patients with urinary tract infection (UTI).
Endothellin-1 (ET-1) is a potent vasoactive peptide that has vasoconstrictive effects.
It has been shown that urinary ET-1 increases in urinary obstructions.
In this study, we measured the urinary ET-1 level in patients with UTI and hydronephrosis of various causes.
In this case-control study, we evaluated the urinary ET-1 level in 45 patients who had UTI and hydronephrosis, serving as a case group, and 45 patients who had UTI without hydronephrosis, serving as a control group.
Urinary ET-1 was quantified using enzyme-linked immunosorbent assay and urinary creatinine (Cr) by Jaffe method.
To rule out the effect of urinary flow rate, the urinary ET-1 to Cr correlation was considered for analysis of the results.
The mean age of the patients in the case and control groups was 36.5 ± 27.2 and 26.2 ± 15.5 months, respectively (P > 0.01).
The mean urinary ET-1 was 89.6 ± 41.7 pg / dL in the case group and 29.3 ± 26 pg / dL in the control group, P < 0.001.
The mean urinary ET-1 was 121 ± 55.4 pg / dL in patients who had grade 4 hydronephrosis.
We conclude that urinary ET-1 was significantly higher in the obstructed than in non-obstructed cases.
Urinary ET-1 could be a useful marker that can be utilized in young children for diagnosis of hydronephrosis, especially obstructive cases
American Psychological Association (APA)
Sharifin, Mustafa& Ahmadi, Mitra& Karimi, Abd Allah& Zand, Rana Ismaili& Mughadar, Ruzbah& Ahmadi, Ruya…[et al.]. 2013. Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 4, pp.731-736.
https://search.emarefa.net/detail/BIM-328642
Modern Language Association (MLA)
Sharifin, Mustafa…[et al.]. Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 4 (2013), pp.731-736.
https://search.emarefa.net/detail/BIM-328642
American Medical Association (AMA)
Sharifin, Mustafa& Ahmadi, Mitra& Karimi, Abd Allah& Zand, Rana Ismaili& Mughadar, Ruzbah& Ahmadi, Ruya…[et al.]. Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 4, pp.731-736.
https://search.emarefa.net/detail/BIM-328642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 735-736
Record ID
BIM-328642