Alveolar hemorrhage and kidney disease : characteristics and therapy
Joint Authors
Krid, Madihah
al-Ati, Zahrah
Rayyis, Lamya
Bin Aysh, Durrah
Bin Mayz, Hadi
Biji, Sumayyah
Zuwaghi, Karim
Bin Fatimah, Layla
Bin Musa, Fatimah
Samawi, Wided
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 4 (31 Dec. 2013), pp.743-750, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-12-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Anti-neutrophil cytoplasmic antibody-associated vasculitis and Goodpasture's glomerular basement membrane disease are the most common causes of diffuse alveolar hemorrhage, a life-threatening disease.
Systemic lupus erythematosus and the antiphospholipid syndrome are also causes of alveolar hemorrhage.
We retrospectively reviewed 15 cases of diffuse alveolar hemorrhage (DAH) associated with renal diseases.
Diagnosis of DAH was based on the presence of bloody bronchoalveolar lavage fluid.
There were three men and 12 women, with a mean age of 50.5 years (extremes: 24-74 years).
Proteinuria and hematuria were observed, respectively, in 15 and 14 cases.
Six patients revealed arterial hypertension.
Crescentic glomerulonephritis was diagnosed with kidney biopsies in ten cases.
The etiology of renal disease was microscopic polyangiitis (MPA) in seven cases, Wegener disease in four cases, systemic lupus erythematous in one case, cryoglobulinemia in one case, myeloma in one case and propyl-thiouracil-induced MPA in one case.
Hemoptysis occurred in 14 cases.
The mean serum level of hemoglobin was 7.1 g / dL (5.1-10 g / dL).
The mean serum creatinine concentration was 7.07 mg / dL (2.4-13.7 mg / dL).
Gas exchange was severely compromised, with an oxygenation index <80 mmHg in 14 patients and <60 mmHg in seven patients.
Bronchoalveolar lavage was performed in 11 cases, and had positive findings for hemorrhage in all.
Methylprednisolone pulses and cyclophosphamide were used in 14 patients.
Plasmapheresis was performed in three cases.
One patient received cycles of Dexamethasome-Melphalan.
Three patients died as a result of DAH.
The mortality rate in our study was 20 %.
American Psychological Association (APA)
Bin Fatimah, Layla& al-Ati, Zahrah& Rayyis, Lamya& Krid, Madihah& Samawi, Wided& Bin Musa, Fatimah…[et al.]. 2013. Alveolar hemorrhage and kidney disease : characteristics and therapy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 4, pp.743-750.
https://search.emarefa.net/detail/BIM-328655
Modern Language Association (MLA)
Bin Fatimah, Layla…[et al.]. Alveolar hemorrhage and kidney disease : characteristics and therapy. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 4 (2013), pp.743-750.
https://search.emarefa.net/detail/BIM-328655
American Medical Association (AMA)
Bin Fatimah, Layla& al-Ati, Zahrah& Rayyis, Lamya& Krid, Madihah& Samawi, Wided& Bin Musa, Fatimah…[et al.]. Alveolar hemorrhage and kidney disease : characteristics and therapy. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 4, pp.743-750.
https://search.emarefa.net/detail/BIM-328655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 749-750
Record ID
BIM-328655