Effect of relative hypoparathyroidism on the responsiveness to recombinant human erythropoietin in chronic hemodialysis patients : a single Saudi center experience
Joint Authors
Sabri, Ala
Hasan, Ashraf H.
al-Saran, Khalid A.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 4 (31 Dec. 2013), pp.825-831, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
- Patients
- الغدة الجار درقية
- Diseases
- Hemodialysis
- Saudi Arabia
- Anemia
- Complications(Medicine)
- Hypoparathyroidism
- Recombinant erythropoietin
Abstract EN
Anemia is a common concomitant disorder in dialysis patients.
The responsiveness to recombinant human erythropoietin in hemodialysis (HD) patients with relative hypoparathyroidism [4 ≤ intact parathyroid hormone (iPTH) ≤ 16.5 pmol / L] remains undetermined.
We retrospectively studied 70 chronic hemodialysis patients who were divided into two groups : Group A (32 patients) had 16.5 ≤ iPTH levels < 33.5 pmol / L and Group B (38 patients) had 4 ≥ iPTH ≤ 16.5 pmol / L during the preceding six months without 1-(OH) Vitamin D3 administration.
The percentage of female gender was significantly higher in Group B compared with Group A (P = 0.018).
In Groups A and B, the mean weekly recombinant human erythropoietin dose (U / kg / week) was 227.96 ± 95.24 vs.
154.1 ± 84.9 (P = 0.001) and the mean hemoglobin level was 11.15 ± 0.63 g / dL versus 11.62 ± 0.63 g / dL (P = 0.008).
There was no significant statistical difference regarding the other biochemical markers (serum ferritin, iron saturation, serum Ca, serum alkaline phosphatase, C-reactive protein, serum B12, serum folate levels, residual renal function and Kt / v) between the groups.
If other factors related to anemia are excluded in chronic HD patients, the lower the iPTH level (relative hypoparathyroidism) the better the responsiveness to recombinant human erythropoietin.
American Psychological Association (APA)
al-Saran, Khalid A.& Sabri, Ala& Hasan, Ashraf H.. 2013. Effect of relative hypoparathyroidism on the responsiveness to recombinant human erythropoietin in chronic hemodialysis patients : a single Saudi center experience. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 4, pp.825-831.
https://search.emarefa.net/detail/BIM-328720
Modern Language Association (MLA)
al-Saran, Khalid A.…[et al.]. Effect of relative hypoparathyroidism on the responsiveness to recombinant human erythropoietin in chronic hemodialysis patients : a single Saudi center experience. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 4 (2013), pp.825-831.
https://search.emarefa.net/detail/BIM-328720
American Medical Association (AMA)
al-Saran, Khalid A.& Sabri, Ala& Hasan, Ashraf H.. Effect of relative hypoparathyroidism on the responsiveness to recombinant human erythropoietin in chronic hemodialysis patients : a single Saudi center experience. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 4, pp.825-831.
https://search.emarefa.net/detail/BIM-328720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 830-831
Record ID
BIM-328720