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Genetic analysis of cagA and vacA genes in helicobacter pylori isolates and their relationship with gastroduodenal diseases in the west of Iran
Joint Authors
Suud, Nijar
Kargar, Muhammad
Doosti, Abbas
Ranjbar, Rida
Sarshar, Maysam
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 5 (31 May. 2013), pp.371-375, 5 p.
Publisher
Publication Date
2013-05-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Helicobacter pylori have different virulence factors which are associated with several gastroduodenal diseases ; however, this association is variable in different geographical regions.
Data of genotypes of Iranian H.
pylori isolates are few.
Objectives : The aim of the current study was to investigate the cagA / vacA genotypes of Helicobacter pylori isolates and determine the relationship between these genotypes with respect to different gastric disorders in patients of Chaharmahalo Bakhtiarian.
Materials and Methods : In this cross-sectional study, gastric biopsies were taken from 200 patients with gastrodoudenal diseases.
Histopathological features were recognized by specialist.
The samples were subjected to PCR for detection and identification of ureC, cagA and vacA genes.
Results : The frequency of the vacA genotypes, sa1 / m1, s1a / m1b, s1a / m2, s1b / m1a, s1b / m1b, s1b / m2, s1c/m1a, s1c / m1b, s1c / m2, s2 / m1a, s2 / m1b and s2 / m2 were 27 (6.6 %), 8 (4.3 %), 45 (28.04 %), 7(3.7 %), 5(2.5 %), 10 (6.1 %), 12 (7.4 %), 4 (2.5 %), 18 (11 %), 6 (3.7 %), 0 and 22 (13.5 %) respectively.
The cagA gene was detected in 92 % of strains.
Based on our findings, it seemed that cagPAI and vacA s1 genotypes were associated with some gastric disorders in patients with H.
pylori.
In this region, the isolates carrying s1a / m2 were the most prevalent.
Conclusions : We found considerable relationship between s1a / m1a, s1a / m2, s2 / m2 and s1c / m1a and some gastric disorders.
Further studies about the role of H.
pylori virulence factors and gastric disorders were recommended.
American Psychological Association (APA)
Suud, Nijar& Kargar, Muhammad& Doosti, Abbas& Ranjbar, Rida& Sarshar, Maysam. 2013. Genetic analysis of cagA and vacA genes in helicobacter pylori isolates and their relationship with gastroduodenal diseases in the west of Iran. Iranian Red Crescent Medical Journal،Vol. 15, no. 5, pp.371-375.
https://search.emarefa.net/detail/BIM-328985
Modern Language Association (MLA)
Suud, Nijar…[et al.]. Genetic analysis of cagA and vacA genes in helicobacter pylori isolates and their relationship with gastroduodenal diseases in the west of Iran. Iranian Red Crescent Medical Journal Vol. 15, no. 5 (2013), pp.371-375.
https://search.emarefa.net/detail/BIM-328985
American Medical Association (AMA)
Suud, Nijar& Kargar, Muhammad& Doosti, Abbas& Ranjbar, Rida& Sarshar, Maysam. Genetic analysis of cagA and vacA genes in helicobacter pylori isolates and their relationship with gastroduodenal diseases in the west of Iran. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 5, pp.371-375.
https://search.emarefa.net/detail/BIM-328985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 375
Record ID
BIM-328985