In vitro cytotoxic and antimicrobial activity of essential oil from satureja intermedia
Joint Authors
Sadiqi, Iman
Yusuf Zadi, Murtada
Behmanesh, Mehrdad
Sharifi, Muzaffar
Muradi, Ayyub
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 1 (31 Jan. 2013), pp.70-74, 5 p.
Publisher
Publication Date
2013-01-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : many members of the genus Satureja have aromatic and medicinal characteristics.
Objectives : the purpose of the present work was to determine cytotoxic activity of the essential oil of S.intermedia CA Mey (Lamiaceae) on two human cancerous cell lines and it's in vitro inhibitory effects against 11 pathogenic bacteria and fungi as well.
Materials and Methods: The essential oil was isolated by hydro distillation and analyzed by combination of capillary GC-FID and GC-MS.
The in vitro toxicological study was based on the MTT cytotoxicity assay and antimicrobial activity of the essential oil was studied according to the disc diffusion method and MIC value.
Results : thymol (34.5 %), γ-terpinene (18.2 %) and ρ-cymene (10.5 %) were the main components of the essential oil.
The toxicological study on 5637 and KYSE cell lines showed IC50 values of 156 μg / ml.
The essential oil exhibited considerable antimicrobial activity on tested bacteria and fungi.
Conclusions : from the results of the present study, it may be concluded that the essential oil of S.
intermedia and its major constitutes are interesting in antibacterial and anticancer applications.
American Psychological Association (APA)
Sadiqi, Iman& Yusuf Zadi, Murtada& Behmanesh, Mehrdad& Sharifi, Muzaffar& Muradi, Ayyub. 2013. In vitro cytotoxic and antimicrobial activity of essential oil from satureja intermedia. Iranian Red Crescent Medical Journal،Vol. 15, no. 1, pp.70-74.
https://search.emarefa.net/detail/BIM-329075
Modern Language Association (MLA)
Sadiqi, Iman…[et al.]. In vitro cytotoxic and antimicrobial activity of essential oil from satureja intermedia. Iranian Red Crescent Medical Journal Vol. 15, no. 1 (2013), pp.70-74.
https://search.emarefa.net/detail/BIM-329075
American Medical Association (AMA)
Sadiqi, Iman& Yusuf Zadi, Murtada& Behmanesh, Mehrdad& Sharifi, Muzaffar& Muradi, Ayyub. In vitro cytotoxic and antimicrobial activity of essential oil from satureja intermedia. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 1, pp.70-74.
https://search.emarefa.net/detail/BIM-329075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 74
Record ID
BIM-329075