Comparison of high frequency positive pressure mechanical ventilation (HFPPV)‎ with conventional method in the treatment of neonatal respiratory failure

Abstract EN

Background : Respiratory failure is a major problem in neonatal medicine in all over the world and has different causes.

Using mechanical ventilation is one of its major treatments.

Objectives : Different strategies have been expressed in this context, including high frequency mechanical ventilation.

Patients and Methods : This study is a prospective randomized clinical trial conducted on all newborns with respiratory failure hospitalized in the NICU of Tehran vali-asr Hospital during 2009.These patients were divided in to two groups through block Randomization method ; conventional mechanical ventilation group and high frequency ventilation group.

Results : Intraventricular hemorrhage (IVH) and air leak (e.g.

pneumothorax) were less in HFPPV group than conventional group (P = 0.012 and P = 0.038).

The mean time needed for mechanical ventilation was lower in HFPPV group, but this difference was not statistically significant (P = 0.922).

Needing to O2 in 28 days of age was almost equal in both groups (P = 0.

99).

Mortality, and refractory hypoxia and PVL were lower in HFPPV group, but the difference was not statistically significant (P = 0.301, P = 0.

508, P = 0.

113).

Conclusions : Treatment of neonatal respiratory failure with high rate mechanical ventilation may reduce some complications.