Transcranial doppler ultrasonography in beta-thalassemia major patients without and with thrombocytosis
Joint Authors
Shariat, Abd al-Hamid
Naziri, Masumi
Furughi, Amin Abulhasani
Karimi, Mahran
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 3 (31 Mar. 2013), pp.234-238, 5 p.
Publisher
Publication Date
2013-03-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Beta-thalassemia is a type of anemia in which the patients may require splenectomy and this can lead to thrombocytosis with increased risk of stroke.
Transcranial Doppler ultrasound is a method for determining cerebral vessel stenosis.
Objectives : The aim of this study was to investigate whether the risk of a future stroke secondary to cerebral artery stenosis can be predicted with the use of transcranial Doppler ultrasound in beta-thalassemia major patients.
Patients and Methods : This study included 54 beta-thalassemia major patients divided into 2 groups ; group A consisted of 28 patients who have thrombocytosis secondary to a previous splenectomy and group B comprised of 26 patients who did not have a splenectomy with normal platelet count, as well as a control group of 30 healthy individuals.
Results : Transcranial Doppler ultrasound of the cerebral vessels were performed in all participants, and the results for each group were compared with the controls.
In addition, patients were evaluated for evidence of high flow velocity in the cerebral vessels that met the clinically significant criteria of ≥ 50 % stenosis.
Transcranial Doppler ultrasound velocity criteria for & gt ; 50 % stenosis, indicating a risk of stroke, were not documented in any patients but increase in cerebral blood velocities in many arteries in group A and in some arteries in group B were revealed.
Conclusion : Following splenectomy, thrombocytosis can predispose the patients to an increase in cerebral blood velocities more than respected with anemia.
But by transcranial doppler ultrasonography no evidence of significant stenosis were found in intracerebral arteries to conclude that the beta-thalassemia major patients were more prone to the development of stroke secondary to this abnormality.
American Psychological Association (APA)
Shariat, Abd al-Hamid& Naziri, Masumi& Furughi, Amin Abulhasani& Karimi, Mahran. 2013. Transcranial doppler ultrasonography in beta-thalassemia major patients without and with thrombocytosis. Iranian Red Crescent Medical Journal،Vol. 15, no. 3, pp.234-238.
https://search.emarefa.net/detail/BIM-329103
Modern Language Association (MLA)
Shariat, Abd al-Hamid…[et al.]. Transcranial doppler ultrasonography in beta-thalassemia major patients without and with thrombocytosis. Iranian Red Crescent Medical Journal Vol. 15, no. 3 (2013), pp.234-238.
https://search.emarefa.net/detail/BIM-329103
American Medical Association (AMA)
Shariat, Abd al-Hamid& Naziri, Masumi& Furughi, Amin Abulhasani& Karimi, Mahran. Transcranial doppler ultrasonography in beta-thalassemia major patients without and with thrombocytosis. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 3, pp.234-238.
https://search.emarefa.net/detail/BIM-329103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 238
Record ID
BIM-329103