Engineering of the embryonic and adult stem cell niches
Joint Authors
Husayn Khani, Muhsin
Shirazi, Rida
Rajaei, Farzad
Mahmudi, Masud
Muhammadi, Navid
Abbasi, Mahnaz
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 2 (28 Feb. 2013), pp.83-92, 10 p.
Publisher
Publication Date
2013-02-28
Country of Publication
United Arab Emirates
No. of Pages
10
Main Subjects
Topics
Abstract EN
Context : Stem cells have the potential to generate a renewable source of cells for regenerative medicine due to their ability to self-renew and differentiate to various functional cell types of the adult organism.
The extracellular microenvironment plays a pivotal role in controlling stem cell fate responses.
Therefore, identification of appropriate environmental stimuli that supports cellular proliferation and lineagespecific differentiation is critical for the clinical application of the stem cell therapies.
Evidence Acquisition : Traditional methods for stem cells culture offer limited manipulation and control of the extracellular microenvironment.
Micro engineering approaches are emerging as powerful tools to control stem cell-microenvironment interactions and for performing high-throughput stem cell experiments.
Results : In this review, we provided an overview of the application of technologies such as surface micropatterning, microfluidics, and engineered biomaterials for directing stem cell behavior and determining the molecular cues that regulate cell fate decisions.
Conclusions : Stem cells have enormous potential for therapeutic and pharmaceutical applications, because they can give rise to various cell types.
Despite their therapeutic potential, many challenges, including the lack of control of the stem cell microenvironment remain.
Thus, a greater understanding of stem cell biology that can be used to expand and differentiate embryonic and adult stem cells in a directed manner offers great potential for tissue repair and regenerative medicine.
American Psychological Association (APA)
Husayn Khani, Muhsin& Shirazi, Rida& Rajaei, Farzad& Mahmudi, Masud& Muhammadi, Navid& Abbasi, Mahnaz. 2013. Engineering of the embryonic and adult stem cell niches. Iranian Red Crescent Medical Journal،Vol. 15, no. 2, pp.83-92.
https://search.emarefa.net/detail/BIM-329110
Modern Language Association (MLA)
Husayn Khani, Muhsin…[et al.]. Engineering of the embryonic and adult stem cell niches. Iranian Red Crescent Medical Journal Vol. 15, no. 2 (2013), pp.83-92.
https://search.emarefa.net/detail/BIM-329110
American Medical Association (AMA)
Husayn Khani, Muhsin& Shirazi, Rida& Rajaei, Farzad& Mahmudi, Masud& Muhammadi, Navid& Abbasi, Mahnaz. Engineering of the embryonic and adult stem cell niches. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 2, pp.83-92.
https://search.emarefa.net/detail/BIM-329110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 90-92
Record ID
BIM-329110