![](/images/graphics-bg.png)
Comparison between preoperative administration of methylprednisolone with its administration before and during congenital heart surgery on serum levels of il-6 and il-10
Joint Authors
Sultani, Qasim
Tashnizi, Muhammad Abbasi
Zirak, Nahid
Moeinipour, Ali Asghar
Tanha, Amir Sabir
Jarahi, Lida
Shamloo, Ali Rida Sepehri
Ayat Allah, Husayn
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 2 (28 Feb. 2013), pp.147-151, 5 p.
Publisher
Publication Date
2013-02-28
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Steroid administration during cardiopulmonary bypass is considered to improve cardiopulmonary function by modulating inflammations caused by bypass.
Objectives : This study was performed to compare effectiveness of preoperative and intraoperative methylprednisolone (MP) to preoperative methylprednisolone alone in post bypass inflammatory (IL-6) and anti-inflammatory (IL-10) factors.
Patients and Methods : Fifty pediatric patients undergoing cardiopulmonary bypass surgery from August 2011 to 2012 in the cardiac surgery department of Imam Reza Hospital, the major center for CPB, in Mashhad, Iran were randomly assigned to receive preoperative and intraoperative MP (30 mg / kg, 4 hours before bypass and in bypass prime, number 25) or preoperative MP only (30 mg / kg, number 25).
Before and after bypass, four and 24 hours after bypass, serum IL-6 and IL-10 were measured by ELISA.
Results: In both groups, no significant difference with variation of expression for IL-6 (inflammatory factor) and IL-10 (anti-inflammatory factor) in different times after bypass was observed.
Conclusions : No significant difference in reducing post bypass inflammation between preoperative steroid treatment and combined preoperative and intraoperative steroid administration reported and they had the same effects.
American Psychological Association (APA)
Tashnizi, Muhammad Abbasi& Sultani, Qasim& Moeinipour, Ali Asghar& Ayat Allah, Husayn& Tanha, Amir Sabir& Jarahi, Lida…[et al.]. 2013. Comparison between preoperative administration of methylprednisolone with its administration before and during congenital heart surgery on serum levels of il-6 and il-10. Iranian Red Crescent Medical Journal،Vol. 15, no. 2, pp.147-151.
https://search.emarefa.net/detail/BIM-329129
Modern Language Association (MLA)
Tashnizi, Muhammad Abbasi…[et al.]. Comparison between preoperative administration of methylprednisolone with its administration before and during congenital heart surgery on serum levels of il-6 and il-10. Iranian Red Crescent Medical Journal Vol. 15, no. 2 (2013), pp.147-151.
https://search.emarefa.net/detail/BIM-329129
American Medical Association (AMA)
Tashnizi, Muhammad Abbasi& Sultani, Qasim& Moeinipour, Ali Asghar& Ayat Allah, Husayn& Tanha, Amir Sabir& Jarahi, Lida…[et al.]. Comparison between preoperative administration of methylprednisolone with its administration before and during congenital heart surgery on serum levels of il-6 and il-10. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 2, pp.147-151.
https://search.emarefa.net/detail/BIM-329129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 150-151
Record ID
BIM-329129