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FISH analysis for del6q21 and del17p13 in b-cell chronic lymphocytic leukemia in Iranians
Joint Authors
Taymuri, Husayn
Ashuri, Saidi
Akbari, Muhammad Taghi
Naeini, Marjan Mojtabavi
Chaleshtori, Murtada Hashim Zadah
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 15, Issue 2 (28 Feb. 2013), pp.107-112, 6 p.
Publisher
Publication Date
2013-02-28
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the Western world.
Major progress has been made in assessing typical chromosomal abnormalities and recognition of the correlation of these chromosomal abnormalities with laboratory features and clinical course of the disease.
The most frequent genomic changes are deletions at 13q14, 11q22-23 and 17p13 and trisomy of chromosome 12.
Objectives : The aim of this study was to investigate the frequency of chromosomal aberrations in B-CLL patients’ peripheral blood and / or bone marrow using a molecular cytogenetic method, interphase fluorescence in situ hybridization (I-FISH) and to evaluate the correlation between these genomic changes and clinical findings.
Patients and Methods : I-FISH analyses were performed on bone marrow and blood samples of 66 B-CLL patients.
Results : Deletion of 17p13 was found in 11 (16.6 %) and deletion 6q21 was present in 5 (7.5 %).
Statistical analyses were performed to investigate the correlation of these molecular-cytogenetic findings with family history, Rai staging and CD38 marker.
No clear differences in distribution was noted for del17p13 and del6q21 among patients with and without family history, and no direct correlation was noted between these genomic changes and CD38 marker, but the correlation of del17p13 and Rai stage was significant.
There was a high frequency of Rai stage II within del17p13 patients.
Conclusions : It was demonstrated that the presence of del6q21 in B-CLL patients indicates poor prognosis and on the contrary, presence of del17p13 points at the good prognostic value of the disease.
American Psychological Association (APA)
Taymuri, Husayn& Ashuri, Saidi& Akbari, Muhammad Taghi& Naeini, Marjan Mojtabavi& Chaleshtori, Murtada Hashim Zadah. 2013. FISH analysis for del6q21 and del17p13 in b-cell chronic lymphocytic leukemia in Iranians. Iranian Red Crescent Medical Journal،Vol. 15, no. 2, pp.107-112.
https://search.emarefa.net/detail/BIM-329179
Modern Language Association (MLA)
Taymuri, Husayn…[et al.]. FISH analysis for del6q21 and del17p13 in b-cell chronic lymphocytic leukemia in Iranians. Iranian Red Crescent Medical Journal Vol. 15, no. 2 (2013), pp.107-112.
https://search.emarefa.net/detail/BIM-329179
American Medical Association (AMA)
Taymuri, Husayn& Ashuri, Saidi& Akbari, Muhammad Taghi& Naeini, Marjan Mojtabavi& Chaleshtori, Murtada Hashim Zadah. FISH analysis for del6q21 and del17p13 in b-cell chronic lymphocytic leukemia in Iranians. Iranian Red Crescent Medical Journal. 2013. Vol. 15, no. 2, pp.107-112.
https://search.emarefa.net/detail/BIM-329179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 111-112
Record ID
BIM-329179