Cytomegalovirus disease in a renal transplant recipient : the importance of pre-transplant screening of the donor and recipient
Joint Authors
Shahin, Faysal
Mitwali, Ahmad Hassan
Nazmi, Ahmad
al-Ghanayim, Muhammad
Kfuri, Hala
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 1 (28 Feb. 2013), pp.80-85, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
A 16-year-old female patient who was born with a single kidney developed chronic kidney disease during her early childhood due to reflux nephropathy and recurrent urinary tract infection.
She progressed to end-stage renal disease (ESRD) and was commenced on renal replacement therapy in the form of peritoneal dialysis in May 2011.
Subsequently, she underwent living unrelated donor kidney transplantation in China.
She was hospitalized soon after returning to Saudi Arabia for management of high-grade fever, shortness of breath, and deterioration of renal function, which was found to be due to cytomegalovirus (CMV) disease, proved by kidney biopsy and presence of high level of anti-CMV immunoglobulins.
Allograft biopsy showed mature viral particles sized between 120 and 149 nm in the nuclei of the glomerular endothelial cells.
The patient was treated with valgancyclovir and specific CMV immunoglobulin, as well as by reducing and even stopping the dose of tacrolimus and mycophenolate.
Despite all these measures, her condition continued to deteriorate and she finally died.
Our study emphasizes that unrelated renal transplantation, especially if unplanned and improperly prepared, is a very risky procedure that might transfer dangerous diseases and increase the morbidity and mortality of the patients.
We strongly stress the need for mandatory and proper screening for CMV carrier status among donors as well as recipients prior to transplantation.
Also, a recommendation is made to reject CMV-positive donors.
American Psychological Association (APA)
Mitwali, Ahmad Hassan& Nazmi, Ahmad& al-Ghanayim, Muhammad& Shahin, Faysal& Kfuri, Hala. 2013. Cytomegalovirus disease in a renal transplant recipient : the importance of pre-transplant screening of the donor and recipient. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 1, pp.80-85.
https://search.emarefa.net/detail/BIM-329702
Modern Language Association (MLA)
Mitwali, Ahmad Hassan…[et al.]. Cytomegalovirus disease in a renal transplant recipient : the importance of pre-transplant screening of the donor and recipient. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 1 (2013), pp.80-85.
https://search.emarefa.net/detail/BIM-329702
American Medical Association (AMA)
Mitwali, Ahmad Hassan& Nazmi, Ahmad& al-Ghanayim, Muhammad& Shahin, Faysal& Kfuri, Hala. Cytomegalovirus disease in a renal transplant recipient : the importance of pre-transplant screening of the donor and recipient. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 1, pp.80-85.
https://search.emarefa.net/detail/BIM-329702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 84-85
Record ID
BIM-329702