Acute tubular necrosis in a patient with paroxysmal nocturnal hemoglobinuria
Joint Authors
Wijiwickrama, Iranga S.
Guniratni, Lalindra
Silva, Chandu Du
Lanarulle, Rushika L.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 1 (28 Feb. 2013), pp.105-108, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-02-28
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
- Patients
- Bone marrow
- Diseases
- Complications(Medicine)
- Kidney tubules
- Kidney failure
- Paroxysmal nocturnal hemoglobinuria
Abstract EN
Acute renal failure (ARF) is a well-recognized complication of paroxysmal nocturnal hemoglobinuria (PNH).
The predominant mechanism is intravascular hemolysis resulting in massive hemoglobinuria ARF.
We report a case of acute tubular necrosis (ATN) developed in the absence of overwhelming evidence of intravascular hemolysis in a 21-year-old man with anemia, who was eventually diagnosed to have PNH.
The patient presented with rapidly deteriorating renal functions in the background of iron deficiency anemia, which was attributed to reflux esophagitis.
There was no clinical or laboratory evidence of intravascular hemolysis.
Renal biopsy revealed ATN with deposition of hemosiderin in the proximal tubular epithelial cells.
Diagnosis of PNH was confirmed with a positive Ham's test and flow cytometry.
Our case emphasizes the need to consider ATN as a possible cause for ARF in patients suspected to have PNH even in the absence of overwhelming evidence of intravascular hemolysis.
American Psychological Association (APA)
Wijiwickrama, Iranga S.& Guniratni, Lalindra& Silva, Chandu Du& Lanarulle, Rushika L.. 2013. Acute tubular necrosis in a patient with paroxysmal nocturnal hemoglobinuria. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 1, pp.105-108.
https://search.emarefa.net/detail/BIM-329720
Modern Language Association (MLA)
Wijiwickrama, Iranga S.…[et al.]. Acute tubular necrosis in a patient with paroxysmal nocturnal hemoglobinuria. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 1 (2013), pp.105-108.
https://search.emarefa.net/detail/BIM-329720
American Medical Association (AMA)
Wijiwickrama, Iranga S.& Guniratni, Lalindra& Silva, Chandu Du& Lanarulle, Rushika L.. Acute tubular necrosis in a patient with paroxysmal nocturnal hemoglobinuria. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 1, pp.105-108.
https://search.emarefa.net/detail/BIM-329720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 108
Record ID
BIM-329720