Thyroid peroxidase antibody in type 1 diabetic patients

Abstract EN

Type 1 Diabetes Mellitus is an autoimmune disease characterized by absolute insulin deficiency resulting destruction of islet beta cells.

T1DM is frequently associated with autoimmune thyroid disease.

We have therefore investigated the prevalence of anti-thyroid peroxidase(anti-TPO) & anti-thyroglobulin (anti-Tg) antibodies in type 1 diabetic patients, and screened anti-thyroid antibodies and TSH, T3, & T4 levels, and to study the level of lipid profile in type 1 diabetic patients and its relation to anti-thyroid antibodies(anti-TPO & anti-Tg) .

Ninety subjects with type 1 diabetes mellitus and thirty healthy as controls non-diabetics under the age of thirty years.

Blood samples were taken for investigation of thyroid function test by using Vitek Immune Diagnostic Assay System(VIDAS).

Enzyme Linked Immuno Sorbent Assay(ELISA) test to detect anti-thyroid antibodies(TPO & Tg).

Among 90 type 1diabetic patients 20(22.2%) were positive for anti-TPO and 7(7.7%) were positive for anti-Tg.

There was a statistically no significant correlation between the levels of (anti-TPO & anti-Tg) and gender in type 1 diabetic patients (P value>0.820 and P value>0.972), respectively.

Also we found another negative ( P value>0.05) correlation between (anti-TPO & anti-Tg) with age.

There was a statistically significant positive correlation between TSH and (anti-TPO & anti-Tg) antibodies levels in type 1 diabetic patients( P value<0.05) at the same time was negative correlation between (T3& T4) levels and (anti-TPO & anti-Tg) levels, but statistically not significant( P value>0.05).

on the other hand we found statistically significant negative ( P value>0.05) correlation between (anti-TPO & anti-Tg) levels and lipid profile levels in type 1 diabetic patients.

Finally, the present study showed that there was statistically significant correlation between (anti-TPO) antibodies level and (anti-Tg) antibodies level ( P value<0.021).