Study the interaction between prolactin hormone and some organotellurium compounds

Abstract EN

In the present study , three organotellurium compounds have been prepared by a simplified methods.

These compounds include; diphenyl ditelluride (compound1), Bis(p-methoxy phenyl) ditelluride (compound3), and p-methoxy phenyl tellurium trichloride (compound2).

These compounds have been prepared from reaction TeCl4 as starting material with some ethers in different solvents.

All these organotellurium compounds were characterized the well-known methods including: FTIR, UV-Visible spectrophotometry, CHN analysis, melting point and H1NMR spectroscopy.

The study of prolactine hormone adsorption on the surface of these compounds showed that the equilibrium time of adsorption was between 30-60 minutes.

Prolactin concentrations were followed by enzyme-linked immunosorbent assay (ELISA) technique.

Tellurium compounds extract good amounts of prolactin from solution on their surfaces and the differences between the absorbed quantities are small.

All absorption process curve were of S-shaped according to Gills classification.

The adsorption isotherm studies showed that most Te compounds obeyed Frundlish equation isotherm indicating the heterogeneity of the energy of the active sites on the organotellurium compounds surface.

Desorption studies show a low desorption percentage, which indicates a strong association between Prolactin and organotellurium compounds.

These properties can be used to immobilize proteins on the surfaces of these compounds as a useful tool in the biochemical researches or in the extraction processes of minute amounts of important proteins from the biological fluids.