Spectrophotometric determination of cefixime through schiff's base system using vanillin reagents inpharmaceutical preparations
Joint Authors
Ahmad, Nayif Rahman
Umar, Farah Khalaf
Source
Iraqi National Journal of Chemistry
Issue
Vol. 2013, Issue 49 (31 Mar. 2013), pp.38-46, 9 p.
Publisher
University of Babylon College of Sciences
Publication Date
2013-03-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract AR
تم وصف طريقة طفيفة سهلة و سريعة و حساسة لتقدير السيف كسين.
تعتمد الطريقة على تكوين قاعده شيف بين مجموعه الأمين للسفكسيم و مجموعه الالديهايد للفانلين لتكوين ناتج اصفر اللون له اقصى امتصص عند طول موجي 414 نانو ميتر.
و وجد بان قانون بير يسري على الكميات التي تتراوحبين2-20 مايكرو غرام / مل بامتصاصية مولارية 8,22 × 104لتر / مول.
سم وتعد الطريقة الحالية بسيطة كونها لا تحتاج إلى تسخين أو تحلل مائي أو استخلاص مذيبي حيث أن المواد الداخلة في تحضير المستحضرات المحللة لا تتداخل مع السيفكسيم مما جعلها طريقة ناجحة للتحليل الروتيني للسيفكسيم بشكله النقي و في مستحضراته الصيدلانية (الكبسول).
Abstract EN
A simple, rapid, accurate and sensitive spectrophotometric method for the determination of cefixime has been developed.
The method is based on the formation of the schiff’s base between the primary amino group present in cefixime and aldehyde group present in the vanillin reagent to produce a yellow colored complex having maximum absorption at 414 nm.
Bees law was obeyed over the concentration range of 2-20μg / ml, with molar absorptivity of 8.22x104 l / mol.cm.
The present method is considered to be simple because it does not need heating, hydrolysis and solvent extraction steps.
The ingredients often formulated with cefixime have been shown not to interfere, and is suitable for the routine determination of cefixime.
The proposed method has been successfully applied for the determination of cefixime in pure form and in pharmaceutical preparations (capsules).
American Psychological Association (APA)
Ahmad, Nayif Rahman& Umar, Farah Khalaf. 2013. Spectrophotometric determination of cefixime through schiff's base system using vanillin reagents inpharmaceutical preparations. Iraqi National Journal of Chemistry،Vol. 2013, no. 49, pp.38-46.
https://search.emarefa.net/detail/BIM-330531
Modern Language Association (MLA)
Ahmad, Nayif Rahman& Umar, Farah Khalaf. Spectrophotometric determination of cefixime through schiff's base system using vanillin reagents inpharmaceutical preparations. Iraqi National Journal of Chemistry No. 49 (Mar. 2013), pp.38-46.
https://search.emarefa.net/detail/BIM-330531
American Medical Association (AMA)
Ahmad, Nayif Rahman& Umar, Farah Khalaf. Spectrophotometric determination of cefixime through schiff's base system using vanillin reagents inpharmaceutical preparations. Iraqi National Journal of Chemistry. 2013. Vol. 2013, no. 49, pp.38-46.
https://search.emarefa.net/detail/BIM-330531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 45-46
Record ID
BIM-330531