Effect of Azadirachta excelsa (Jack)‎ leaf extracts on the reproductive organs and fertility of male albino mice (Mus musculus)‎

Abstract EN

This study was conducted to investigate the effect of oral dose (250 mg / kg body Weight / day, for 21 days) of each aqueous and alcohol leaf extract of Azadirachta excelsa on histological structure of the testis and fertility of male albino mice Mus musculus.

Histological structure of the testis of both treated groups showed affected seminiferous tubules indicating mixing of the germ cell types in stages of spermatogenesis, atrophy of the spermatogenic elements, increases in number of Leydig cells, occurrence of giant cells and decrease s or absence of the spermatozoa in the lumen of the seminiferous tubules as compared with control group.

The other alternations of both treated groups were decrease in number of the spermatozoa in the Ductus epididymidis.

The fertility index of the treated groups was reduced, this result which proves the fertility was observed in untreated females after mated with treated males.