Spectrophotometric determination of chlorocresol via nitrosation reaction-application to pharmaceutical preparations (creams)‎

Abstract EN

A spectrophotometric method for the determination of pure chlorocresol and in number of its pharmaceutical preparations (creams) has been developed that offers advantages of simplicity, sensitivity and stability.

The proposed method was based on the formation of a nitroso derivative of chlorocresol.

The colored product has maximum absorption at 424 nm.

Beer's law is obeyed over the concentration range of (2-26) ppm, with a molar absorptivity of 0.417 × 104 l.mol-1.cm-1.

Relative standard deviation of the method was better than ± 1.8 % and the average recovery was 99.2 %.

The proposed method has been successfully applied to the determination of chlorocresol in pure form and in pharmaceutical preparations (creams).