Histological study of the liver and kidney of albino mice Mus musculus exposed to lead

Abstract EN

The present study was performed to investigate the histological effects caused by lead in the liver and kidney of male albino mice Mus musculus.

The study was conducted on 25 mice, the animals were divided into 5 equal groups.

The first group was given distilled water and used as a control group.

The second and third groups were orally administered (2 and 4 mg lead acetate / kg of body weight) for two weeks.

The fourth and fifth groups were orally administered (2 and 4 mg lead acetate / kg of body weight) for four weeks.

The animals were anesthetized, the (liver and kidneys) were extracted for histological studies.

Histological changes which observed in the liver were, vacuolation, fatty degeneration, necrosis in some hepatocytes, congestion within central veins, hemorrhage between hepatic cords and infiltration of inflammatory cells.

In the kidney the changes noted were hemorrhage in the interstitial tissue with enlargement of epithelial layer lining renal tubules, necrosis of some tubules with hyalinization and focal inflammatory cells infiltration.

In this study deleterious toxic effects observed in liver and kidney.