Anti-Nociceptive effect of rhizome of zingiber officinale (ginger)‎, apple vinger and their combination on animal models of pain in laboratory rats

Abstract EN

This study was performed to investigate the anti-nociceptive effect of aqueous extract of Zingiber officinale rhizomes by three animal models of pain (hot plate test , tail flick and formalin test.

The results showed that the oral administration of aqueous extract of ginger caused (81%) increase in hot plate time, (100%)increase in tail flick time and (41%)decrease in number of licking and biting with respect to pre-administration number.

While the rats that given apple vinegar only caused (79%)increase in hot plate time, (83%) increase in tail flick time and (47%)decrease in number of licking and biting with respect to pre-administration levels.

When the ginger was mixed with vinegar, it showed only (85%)increase in hot plate test, (77%) increase in tail flick test and (63%) in formalin test.