Assessment of anticardiolipin and antiphosphatidylserine antibodies in women with recurrent abortion

Abstract EN

Objective : To assess the prevalence of anticardiolipin (ACL) and antiphosphatidylserine (APS) antibodies in women with repeated abortion in Mosul region.

Methods : Women with history of three or more recurrent spontaneous abortions in their first trimester were studied, for ACL and APS antibodies in their sera by enzyme linked immunosorbent (ELISA).

Fifty normal pregnant women during the first trimester were included as a control.

Chi–squared test was utilized for evaluation.

Results : One hundred–sixty women were tested.

ACL and APS were detected in 45 / 160 (28 %) & 22 / 160 (13.7 %) respectively.

These antibodies were negative in all control group.

Conclusion : Positivisty of ACL antibodies among women with recurrent spontaneous abortion is a common finding in Mosul region.

The use of low dose aspirin plus heparin in management of such women had successful result.