Human cytomegalovirus up-regulates nuclear factor-κB in women with spontaneous abortion
Author
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 50, Issue 4 (31 Dec. 2008)4 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2008-12-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : human cytomegalovirus (HCMV) infection during pregnancy causing serious problems through induction of viral genes that enhance the expression of different cellular factors ending in failure of pregnancy.
Patients and Methods : paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein, and in situ hybridization technique to detect nuclear factor-κB (NF-κB) mRNA.
Results : only nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a significantly higher expression of NF-κB in HCMV positive cases as compared with HCMV negative and the control group (p = 0.001).
Conclusion : this study strengthen the possibility that HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the expression of the transcriptional factor ; NF-κB.
American Psychological Association (APA)
al-Ubaydi, Asma Baqir. 2008. Human cytomegalovirus up-regulates nuclear factor-κB in women with spontaneous abortion. Journal of the Faculty of Medicine Baghdad،Vol. 50, no. 4.
https://search.emarefa.net/detail/BIM-331592
Modern Language Association (MLA)
al-Ubaydi, Asma Baqir. Human cytomegalovirus up-regulates nuclear factor-κB in women with spontaneous abortion. Journal of the Faculty of Medicine Baghdad Vol. 50, no. 4 (2008).
https://search.emarefa.net/detail/BIM-331592
American Medical Association (AMA)
al-Ubaydi, Asma Baqir. Human cytomegalovirus up-regulates nuclear factor-κB in women with spontaneous abortion. Journal of the Faculty of Medicine Baghdad. 2008. Vol. 50, no. 4.
https://search.emarefa.net/detail/BIM-331592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-331592