Human cytomegalovirus up-regulates nuclear factor-κB in women with spontaneous abortion

Abstract EN

Background : human cytomegalovirus (HCMV) infection during pregnancy causing serious problems through induction of viral genes that enhance the expression of different cellular factors ending in failure of pregnancy.

Patients and Methods : paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein, and in situ hybridization technique to detect nuclear factor-κB (NF-κB) mRNA.

Results : only nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a significantly higher expression of NF-κB in HCMV positive cases as compared with HCMV negative and the control group (p = 0.001).

Conclusion : this study strengthen the possibility that HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the expression of the transcriptional factor ; NF-κB.