Soft tissue tumors : histopathological study of 93 cases

Abstract EN

Objective : histopathological and immunohistochemical examination of soft tissue tumors to assess the value of these techniques in verifying the primary diagnosis and their classification.

Methods : A prospective study of 93 consecutive soft tissue biopsies that reached the department of histopathology, central labs, Dohuk, and application of immunohistochemical markers on 27 biopsies.

Results : out of 93 soft tissue tumors, 70 (75.2%) were benign with mean age 27.6 y.

and 23 cases 24.8 % were malignant with mean age 39.1 y..

Immunohistochemistery was performed in 27 cases 21 77.7 % cases of malignant tumors and 6 (22.3 %) benign cases.

The most common benign tumors were Lipoma, Haemangioma, Neurofibroma, while malignant muscle tumors (leiomyosarcoma and Rhabdomyosarcoma) and malignant round cell tumors (Ewing’s sarcoma / PNET) were the major groups.

Conclusion : high quality H and E stained section, remain the best method for establishing the primary diagnosis of soft tissue tumors, but immunohistochemical examination proved extremely helpful in sub classifying them, where 7 out of 9 cases of gastrointestinal tumors (GISTs) showed strong immunoreactivity with (c–kit proteins) CD117, CD34, while other (non GISTs) tumors were negative.