Lipid profile and antihypertensive drugs

Abstract EN

Background : Hypertension and dyslipidemia are cardiovascular risk factors that commonly coexist. Objective : To evaluate the effects of ß - blocker (Atenolol) , ACE inhibitor (Captopril) calcium Channel blocker (Nefidipin ) and diuretics on serum lipid profiles . Method : Thirty untreated hypertensive and 147 hypertensive patient treated with these antihypertensive drugs, attending different public health clinics in Basrah pronivce were enrolled in this study. Serum lipid profile were determined enzymaticaly using kits from BioMerieux, France. Result : The study has revealed that ß-blocker do not significantly affect total cholesterol ( TC ) and LDL- cholesterol , but increase significantly triglyceride (TG) and VLDL –cholesterol and decrease HDL – cholesterol. Diuretics causes a significant elevation of TG with generally no significant changes in TC, LDL – cholesterol , VLDL – cholesterol and HDL-cholesterol.

ACE inhibitor and calcium channel blockers appears to have no significant effect on plasma lipids. Conclusion :It may important to measure blood lipid levels to identify pre-existing hyperlipidemia before starting the antihypertensive therapy and to select antihypertensive agent that will not influence the lipid profile or interfere with the therapy of hyperlipidemia