Metformin : the treatment of choise in polycystic ovary disease

Abstract EN

Aim of study : Was to determine wheather metformin which reduces hyperinsulinemia, would reverse the endocrinopathy of PCOS, allowing resumption of regular , normal menses.

Subjects and Methods : A study included 29 patients with PCOS were treated with metformin for 3-6 months and effects on regulation of menstrual cycles, weight reduction, improvement in endocrinopathy was assessed after treatment.

Results : Of 29 patients with PCOS, with menstual irregulation, the analysis showed that 20 patients resume normal menses after metformin therapy, 14 patients loss weight, and there was reduction in level of blood insulin and testosterone after treatment.

Conclusion : Safe and effective therapy with metformin in PCOS reverses endocrinopathy, restores normal menstrual cycles, and restores fertility, allowing pregnancy.