Single oral dose of fosfomycin trometamol versus ciprofloxacin for UTI prophylaxis in invasive urodynamics : a prospective randomized double blind clinical trial

Abstract EN

The aim is to test the efficacy of a single oral dose of fosfomycin trometamol in preventing urinary tract infection as compared to ciprofloxacin in patients undergoing invasive urodynamics studies.

Patients were randomized into 2 groups: A and B.

Group A: a random group of patients undergoing urodynamics studies received a single pre-procedure dose of fosfomycin trometamol 3 gms orally 3 hours before the study.

Group B: a random group of patients received a single pre-procedure dose of 500 mg ciprofloxacin 3 hours before the study.

A total of 65 patients enrolled in the study (45 females and 20 males); the age range from 10 to 75 years with a mean of 50.32 ± 13.5.

There were 39 patients in group A and 26 patients in group B.

The post-procedure urine analysis showed increased presence of WBCs in Group A (fosfomycin trometamol) compared to group B (ciprofloxacin).

Post-procedure, the negative urine cultures were reduced from 59 % to 20.5 % for group A and comparably from 57.7 % to 23.1 % in group B.

A single dose of both fosfomycin trometamol and ciprofloxacin were equally in-effective in the prophylaxis against UTI in patients undergoing urodynamics studies.