High expression of P 53 protein in recurrent pregnancy loss could play a role in the pathology

Abstract EN

Background : Recent data provide evidence that p53 plays a critical role in mediating pregnancy by regulating steroid hormone activation.

Objective : localization of semi quantitation tof por protein at the materno-fetal interface, in patients with recurrent pregnancy loss.

Methods : Immunohistochemistry analysis of p53 protein using paraffin embedded sections of curate samples obtained from 40 women, who where divided into three groups: 24 women with RPL, 10 women with abortion for the first time, and 6 women with induced abortion.

Results : The mean value of the expression of p 53 protein in the RPL group was (65.8 ± 2.16), which is significantly higher than that of the second group (48.0 ± 2.81), and the third group (50.0 ± 4.66), (p = 0.000).

Conclusion : High expression of p 53 protein in women with RPL may have a role in accelerating placental apoptosis leading to failure of pregnancy.