Protective effect of ethanolic ginger extract against cadmium toxiciy in male rabbits

Abstract EN

This study was done to evaluate the hypoglycemic potentials of ginger (zingiber officinale ) in controlling hyperglycemia, hypoinsulinemia and their effect on total cholesterol in cadmium-induced pancreotoxicity in male rabbits Twenty four of adult male rabbits were divided randomly into four equal groups. Group 1 was given distilled water orally and considered as control group, group 2 received 10mg/kg B.

w of cadmium chloride, group 3 received 100mg / kg B.

w of ginger extract plus 10mg/kg B.

w of cadmium chloride and group 4 received 200mg / kg B.

w of ginger extract plus 10mg / kg B.

w of cadmium chloride.

All treatments were given a daily dose for 35 days. The blood sample was taken from these animal groups after 35 days of treatment for biochemical analysis to estimate : insulin hormone, blood glucose, total cholesterol, Aspartate amino transferase (AST), Alanine aminotranferase (ALT) and Alkaline phosphatase (ALP). The results showed that cadmium chloride administration resulted in a decrease in the level of insulin concentration associated with an increase in glucose and total cholesterol concentration in rabbits.

The enzyme activities of serum ALT, AST and ALP were also significantly increased.

While, the groups of animal that received ginger showed significant decrease in serum glucose, cholesterol, AST, ALT and ALP.

The level of insulin was also increased in these groups of animal.