Effect of vitamin C and zinc on some biochemical parameter in alloxan induced diabetic rabbits

Abstract EN

Diabetes mellitus (DM) a disease which is characterized by hyperglycemia, lipoprotein abnormalities and oxidative stress.

This study was undertaken to investigate the beneficial effect of vitamin C and Zinc on some biochemical parameter when induced diabetic in rabbits by alloxan.

Male rabbits groups divided into four groups : Group I (Negative control) received normal saline orally, alloxan diabetic rabbits : Group II (Positive control) received normal saline orally , while Group III were orally administered 50 mg / kg body weight of vitamin C and group IV were orally administered 100 mg/kg body weight Zinc for 15 days.

The results showed that vitamin C administration and zinc significantly (P < 0.05) reduced the serum glucose, total cholesterol, triglyceride, ALT and AST concentration, while there were significant changes (p< 0.05) was observed on the serum levels of total protein, albumin, globulin and albumin/ globulin ratio in diabetic group treated with vitamin C, Zinc respectively.