The effects of aspirin and fenugreek seed on the testes of white mice

Abstract EN

Background : Fenugreek seeds are used as food ingredient in traditional medicines ; also aspirin is an incredible chemical with many useful benefits in the medical field.

The objective was to study the effect of aspirin and fenugreek on testes of mice.

Method : 20 white male mice weighing (18-23gm) were divided into four groups 5 each.

Group 1, represented control, group 2, mice treated with fenugreek seed (100mg / KgB.

W), group 3 mice treated with aspirin (10mg / Kg B.

W), group 4 mice treated with aspirin and fenugreek seed for 21 days.

Body weight and testes weights were recorded.

Histopathological examination of testes was carried out.

Results : a significant decrease (P < 0.05) in body weight of mice treated with aspirin when compared to the other groups.

A significant decrease (P < 0.001) in testicular weight of mice treated with aspirin as compared to control and other groups was noted.

Structural changes in testes have shown that : aspirin administration caused a decrease in seminiferous tubules diameter associated with increase in connective tissue between them and basement membrane thickness of seminiferous tubules.

While fenugreek seed reverse these changes.

Conclusion : fenugreek seeds exhibited antioxidant property that could ameliorate the alternations induced in mice treated with aspirin.

Further studies are needed to be done on mammals to support our findings.