Histopathological and enzymatic study on the effect of Aspergillus Fumigatus in mice
Joint Authors
Shafiq, Shadha A.
al-Jufi, Iqbal K.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 52, Issue 4 (31 Dec. 2010), pp.480-483, 4 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2010-12-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : Aspergillus fumigatus is a ubiquitous and opportunistic fungal pathogen causing sever invasive aspergillosis, an important source of morbidity and mortality in immunocompromised hosts (human and animals) .The present study was conducted to obtain more clarification about the toxicity and histopathological effects of this pathogen in albino mice.
Material and Methods : fourteen male mice (6-10) weeks old, (20–28) gm weight, divided into two groups , test group (n = 8), intranasally infected with 25μl (710 conidia / ml normal saline ) of A.
fumigatus for 7 successive days, compared with uninfected group (n = 6).
The weight of all animals were measured at the beginning and at the end of the experiment , in addition to histological study for lung, liver and kidney were performed, with estimation of enzyme activity of GOT (Glutomic Oxaloacetic Transaminase), GPT (Glutamic Pyruvic Transaminase), ALP (Alkaline Phosphatase) and Creatinine Kinase in homogenized liver and kidney tissues were studied by colorimetric method.
Results : increased (p < 0.05) in body weight, and organs weight (lung, liver, kidney) in infected mice with different histological changes were found in organs tissues of infected mice especially in lung and liver, these changes were supported by variation in enzyme activities of GOT, GPT, ALP and Creatinin kinase in homogenized organs tissues Conclusion : normal host can suffer from systematic diseases after inhalation of infective forms of A.
Fumigatus (conidia), and further work is needed to study the active components, which are responsible for pathogenesis of this opportunistic fungi.
American Psychological Association (APA)
Shafiq, Shadha A.& al-Jufi, Iqbal K.. 2010. Histopathological and enzymatic study on the effect of Aspergillus Fumigatus in mice. Journal of the Faculty of Medicine Baghdad،Vol. 52, no. 4, pp.480-483.
https://search.emarefa.net/detail/BIM-335997
Modern Language Association (MLA)
Shafiq, Shadha A.& al-Jufi, Iqbal K.. Histopathological and enzymatic study on the effect of Aspergillus Fumigatus in mice. Journal of the Faculty of Medicine Baghdad Vol. 52, no. 4 (2010), pp.480-483.
https://search.emarefa.net/detail/BIM-335997
American Medical Association (AMA)
Shafiq, Shadha A.& al-Jufi, Iqbal K.. Histopathological and enzymatic study on the effect of Aspergillus Fumigatus in mice. Journal of the Faculty of Medicine Baghdad. 2010. Vol. 52, no. 4, pp.480-483.
https://search.emarefa.net/detail/BIM-335997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 483
Record ID
BIM-335997