Synthesis and study biological activity of some new isoxazoline and pyrazoline derivatives

Abstract EN

This work involves synthesis of novel Schiff bases derivatives contining isoxazoline or pyrazoline units starting with chalcons.

4-Aminoacetophenone was reacted with 3-nitrobenzaldehyde in basic medium giving chalcone [I] by claisen-schemidt reaction.

The chalcone [I] was reacted with hydroxylamine hydrochloride giving isoxazoline [II] in basic medium.

The chalcone [I] could also react with hydrazitne hydrate to give pyrazoline [III].

The novel Schiff bases with structural formula [IV] and [V] were prepared by the reaction of amino compounds ; isoxazoline [II] and pyrazolines [III] with p-substituted aldehydes or p-subsituted ketones, respectively in dry benzene using drops of glacial acetic acid as a catalyst with reflux.

All the synthesized compounds have been characterized by melting points, FTIR and 1HMNR (of some of theme) spectroscopy.

The biological activity of all compounds was examined against antibacterial ; gram (+) and gram (-).