Synthesis and antibacterial evaluation of some pyrano-1, 3--oxazine derivatives

Abstract EN

Some dipeptide amide and amino derivatives of 7-chloro-4,5-dioxopyrano [3,4-e]-l,3-oxazine, compounds (2a-d) and (3a-e) respectively have been synthesized and studied against five species of bacteria in vitro.

A significant activity against staph.

Aureus and Bacelus Subtilis were observed by the above derivatives at concentration ranging from (0.1-10 mg.

/ ml.) and remarkable activity was exhibited by 2-(N-glycyl glycine amido)-7-chloro-4,5-dioxopyrano [3,4-e]-l,3-oxazine (2a).

Other compounds showed no significant activities.

The I.R.

and NMR spectral data of the synthesized compounds were also discussed and are included.