Chemoselective synthesis and reactions of some new thiophthalimidines and 3-ethoxythiophthalimidines

Abstract EN

A number of phthalimidines (6) and 3-ethoxyphthalimidines (3) were synthesized by the reduction of the corresponding phthalimides under different conditions.

Treatment of the formers with diphosphorous pentasulfide (P2S5) in dry dioxane afforded the thio derivatives (7) and (4) respectively.

Reaction of (7) and (4) with ethyl amine gave imines (8) and (5), respectively.

Hydrolysis of the imines restored the starting (6) and (3).

The structure of all compounds were identified by physical, chemical and spectroscopic data.