The possible association of HLA class II with bladder cancer in Iraqi patients

Abstract EN

Background : - Genetic Factors have a major role in the development of bladder cancer.

Objectives : - This study was carried out to shed a light on the possible association of HLA class II antigens and BC patients and to correlate this finding with the family history.

Patients and Methodes :- Lymphocytotxicity assay had been used to assess HLAtyping of 65 BC patients and 50 healthy controls.

Results :- comparison between BC patients and healthy controls showed several antigens deviations in their frequencies.

HLA-DR1, HLA-DQ1 and HLA-DQ3 antigens were observed with increased frequencies in patients group with significant differences (P = 0.000, 0.000 and 0.017 respectively).

Moreover there was decrease frequency of HLA-DR7 in patients group (P = 0.010).

Stastical analysis showed non significant correlation of the specific HLA–Ags with family history.

Conclusions : - This finding demonstrated that HLA-DR1, DR7, DQ1 and DQ3 might play a role in BC susceptibility.

• Department of clinical biochemistry.

Collage of Medicine Al-Mustansyriah University • Department of Microbiology.

Collage of Medicine.

Baghdad University • Ministry of Health.