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Effect of ethanol extract of calotropis procera root bark on carbon tetrachloride-induced hepatonephrotoxicity in female rats
Joint Authors
Dahiru, Daniel
Amos, Augustine
Sambo, Sarah H.
Source
Jordan Journal of Biological Sciences
Issue
Vol. 6, Issue 3 (30 Sep. 2013), pp.227-230, 4 p.
Publisher
The Hashemite University Deanship of Academic Research and Graduate
Publication Date
2013-09-30
Country of Publication
Jordan
No. of Pages
4
Main Subjects
Abstract EN
Calotropis procera root is used in traditional medical practice for the treatment of various ailments.
The possible hepatoprotective and nephroprotective activities of the ethanolic extract of C.
procera root in female rats were investigated.
Carbon tetrachloride (CCl4) was used to induce hepatotoxicity and nephrotoxicity with significant (P < 0.05) increase in the level of serum enzyme markers of hepatotoxicity and nonenzyme markers of nephrotoxicity.
Administration of 150 and 300 mg / kg body weight (bw) of the ethanolic extract of C.
procera root did not protect the liver and kidney from CCl4-induced toxicity.
Pretreatment with the extract rather potentiated the toxicity induced by CCl4.
This research result did not support the reported hepatoprotective activity of the extract.
It is advised strongly that caution should be taken when ingesting alcoholic preparations of C.
procera root.
American Psychological Association (APA)
Dahiru, Daniel& Amos, Augustine& Sambo, Sarah H.. 2013. Effect of ethanol extract of calotropis procera root bark on carbon tetrachloride-induced hepatonephrotoxicity in female rats. Jordan Journal of Biological Sciences،Vol. 6, no. 3, pp.227-230.
https://search.emarefa.net/detail/BIM-340314
Modern Language Association (MLA)
Dahiru, Daniel…[et al.]. Effect of ethanol extract of calotropis procera root bark on carbon tetrachloride-induced hepatonephrotoxicity in female rats. Jordan Journal of Biological Sciences Vol. 6, no. 3 (Sep. 2013), pp.227-230.
https://search.emarefa.net/detail/BIM-340314
American Medical Association (AMA)
Dahiru, Daniel& Amos, Augustine& Sambo, Sarah H.. Effect of ethanol extract of calotropis procera root bark on carbon tetrachloride-induced hepatonephrotoxicity in female rats. Jordan Journal of Biological Sciences. 2013. Vol. 6, no. 3, pp.227-230.
https://search.emarefa.net/detail/BIM-340314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 229-230
Record ID
BIM-340314