Secretory and circulatory secondary cryglobulinemia in pulmonary tuberculus patients

Abstract EN

Serum secondary Cryglobulinemia are rarely reported in myeobacterial diseases and even not reported in mucosal arm in men.

Thus fifty pulmonary tuberculosis patients (Aldamaluji 1972) were diagnosed at Hilla centre for respiratory disease during the period of Jan 2009–Mar.

2010.

This together with 25 apparently normal subject as control of the same age groups with patients.

Five mls.

Blood and seven mls of urine sample have been collected from patients and controls.

These were processed for cryocrit percentage, cryglobulinemia separation, CRP and RF following the Irish recommendation 2006 as well as anti-tuberculus antibodies detection, in addition to immunoglobulin immunofrxation.

Three secretion patterns for CRP, RF and anti-tuberculus antibodies were noted as both in serum and secretory urine Cryglobulinemia, in serum only and nill in both.

Thus two types of cryoglobulin are found circulatory and secretory.

Based on the results obtained ; four humeral immunoprofiles in serum and three profiles in urine cryoglobulins were suggested.

There may be an immunodomenant epitope cryoative, inducing cryoglobulin responses, cryoautoreactive epitope inducing RF and a peptide inducing cryoacute phase protein C.

responses.

The immunofixation studies revealed that serum cryoglobulins are of mixed types of Ig.G –IgA– IgM classes.

Thus such Cryglobulinemia is of mixed secondary type, which occupied class in between II & III.